In front of me is a fresh piece of evidence: a paper in Science Translational Medicine 📄🧪 about a new crime-scene method in MS—SV2A-PET with [18F]UCB-H. A radioactive mini-tracer that attaches to synapses and makes them visible on PET 🔦🧠. A flashlight for the contact points between nerve cells 🔌.

Während ich über das so eben gelesene Paper zur Kernidentität des Neurologen von Joseph E. Safdieh und Mathew Stuart Robbins nachdenke, spüre ich förmlich den freundlichen Schlag auf die Stirn. Wir alle verlieren uns zu gern in unseren schönen Nischen – ich als begnadeter MS-Spurensucher voran – und vergessen dabei, was uns eigentlich ausmacht: Ana...

In the brain, dear readers, there’s more than just neurons. There’s a kind of internal task force: the microglia. Think of them as garbage collectors, firefighters, and traffic cops all in one. When something breaks, they clean up. When inflammation arises, they step in. But – as with any police force – too much action can cause collateral damage. ...

Not just your average inflammatory edge, but a kind of fortified wall, a siege rampart of activated macrophages, microglia, and molecular chaos. Some of these rims reached 1.7 mm in thickness, bristling with immune cells armed with cytokines, stress signals, and apoptotic markers ...

Multiple Sclerosis is a chameleon of diseases—sometimes loud and dramatic, with relapses and visible lesions. But PIRA is different. No fever, no contrast enhancement. And yet: the patient walks slower, thinks less clearly, lives more restricted.

We long believed the dura mater — the brain’s outermost membrane — to be merely a protective coat. But the latest evidence? It’s more than that. It’s a distribution hub. Through tiny openings known as ACE points (Arachnoid Cuff Exits), cerebrospinal fluid (CSF) is channeled out like secret passages beneath a Victorian mansion.